Puneeth Iyengar, MD, PhD, UT Southwestern Medical Center, Dallas, TX, describes outstanding issues in utilizing radiotherapy in non-small cell lung cancer (NSCLC), which has limited efficacy in oligometastatic NSCLC. Elucidating predicative and prognostic biomarkers are necessary to enhance outcomes in this subset of patients, as well as finding the right time to administer radiotherapy. Dr Iyengar additionally comments on dosing strategies and the role of measuring progression-free survival (PFS) and circulating tumor DNA (ctDNA). This interview took place at the IASLC 2022 North America Conference on Lung Cancer (NACLC 2022).

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