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1. Introduction to Cardiac Glycoside in Hindi by Solution Pharmacy [ Ссылка ]
2. Cardiac Glycoside Containing Drug- Digitalis (Part 1) by Solution Pharmacy [ Ссылка ]
DIGITALIS LANATA
Synonym
Grecian Foxglove, Wooly foxglove
Biological Source
It consists of the dried leaves of Digitalis lanata J. F. Ehrh., belonging to family Scrophulariaceae.
Geographical Source
It is mainly found in Central and Southern Europe, England, California and India.
Characteristics
The leaves are sessile, linear-lanceolate, about 30 cm long and 4 cm broad with entire margin and apex is acuminate. The veins leave the midrib at an acute-angle. The epidermal cells are beaded with anticlinal walls, has 10–14 celled nonglandular trichomes, and the glandular one.
Chemical Constituents
Digitalis lanata contains cardiac glycosides like lanatoside A, B, C and E. Lanatosides A and B are acetyl derivatives of purpurea glycosides A and B respectively. Hydrolysis of Lanatoside C yields digoxin, a crystalline active glycoside.
Uses
It has gained much importance in recent years because of the less cumulative effect and three to four times greater activity than D. purpurea. They have the same actions as that of the D. purpurea. It is the commercial source of digoxin. Employed in the treatment of auricular fibrillation and congestive heart failure. Their use should always be supervised by a qualified practitioner since in excess they cause nausea, vomiting, slow pulse, visual disturbance, anorexia and fainting.
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