Here is my personal Metal rhythm patch for the Yamaha THR10X.

The secret to getting beefy, low/mid midrange is to use the phaser like the settings in the picture at the end of this video. What a huge difference! The tone becomes much thicker, less hollow & much more aggressive.

There is an Ibanez TS-9 in front of the amp - gain at minimum, level at 3:00 and tone at 12:00.

Guitar: PRS SE 2015 Custom 24 (stock)
Amp: Yamaha THR10X
Pedal: Ibanez TS-9

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