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Employees of DOT-regulated employers who perform or could perform tasks that have been defined as "safety-sensitive" are subject to drug and alcohol testing. This includes over 12 million workers employed as airline pilots, bus drivers, commercial truck drivers, crew members on cargo ships, train engineers, and many others. Employers are required to implement a Drug and Alcohol Program and provide clear explanations of company policies and DOT testing regulations. They must also employ a Designated Employee Representative (DER) to administer the program, receive test results, remove employees from safety-sensitive duties when required, and answer questions about the program and testing process.

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