#supplements #liverhealth #gallbladderproblems #tudca #digestiveproblems
How Does TUDCA work?
TUDCA and the combination of NAC (N-Acetyl Cysteine) ameliorates any issues with the liver.
It may be taken with or without food. I recommend taking it without food to support absorption. If your gallbladder has been removed, taking it with food may aid in digestion.
TUDCA works either by its interactions with other bile salts or by preventing cells from apoptosis. Gallstones Taking bile salts is a long-established way for people to prevent gallstones. TUDCA also helps to dissolve gallstones that may already be forming.
Bile Acid + Taurine = Taurocholic + Taurochenodeoxycholic acid. TUDCA for short.
TUDCA - Tauroursodeoxycholic—Bile Acid It is a bile acid that is found in trace amounts in the human body. Bile acids are compounds released from the gallbladder that help digest fats.
Mechanism:
1- Increasing Glucose-induced insulin release via the cAMP/PKA pathway --- increasing insulin sensitivity.
2- Relieving the Endoplasmic Reticulum (ER) stress. The ER makes the proteins for the cell: Smooth & Rough Endoplasmic Reticulum.
3- Reducing programmed cell death in healthy cells. Prevents the molecule: BAX from reaching the cell. BAX causes mitochondria to release Cytochrome C, which causes enzymes (capases) to initiate apoptosis.
4- Inactivating Bcl-2 associated death promoter: a molecule involved in apoptosis -- 'controls cell death'.
5- Removing toxic bile acids from the liver and preventing them from damaging liver cells.
TUDCA has also been found to reduce oxidative stress, suppress apoptosis, and decrease inflammation.
Dosage:
A dose-response study of TUDCA tested doses of 500 mg, 1000 mg, and 1500 mg per day over six months, finding that there was little difference between the doses on liver marker.
1500 mg was the most effective at lowering enzyme levels while 500 mg was the most cost-effective.
In liver transplant patients, 500 mg of TUDCA taken daily for one year was not associated with any adverse effects.
In patients with PBC, 750 mg of TUDCA daily for two months was well-tolerated. Another study in patients with PBC found 1500 mg of TUDCA daily for six months was also well-tolerated.
What Is TUDCA? Tauroursodeoxycholic—Bile Acid Benefits?
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What Is The Difference Between Ox Bile and TUDCA?
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DR. JINAAN JAWAD
D.C., DACNB, FACFN, FIAMA, CFMP
Dr. Jawad is a Board Certified Chiropractic Neurologist and Acupuncturist. In addition, a Diplomat for the American Chiropractic Neurology Board, Fellow of the American College of Functional Neurology as well as Fellow of the International Academy of Medical Acupuncture. He is a Certified Functional Medicine Practitioner.
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