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BRCA1 and BRCA2 testing criteria offers high clincal sensitivity for ATM, PALB2 and CHEK2 carriers in a multigene panel.

Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant cancer predisposition syndrome caused by germline BRCA1 and BRCA2 mutations. Mutations in these two highly penetrant genes increase the chance for cancer of the breast, ovaries and Fallopian tubes, pancreas and prostate.

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