Nash Family Research Scholar Awardees:

Allison Waters, PhD, Assistant Professor, Psychiatry and Neuroscience
James Murrough, MD, Associate Professor, Psychiatry and Neuroscience
Helen Mayberg, MD, Professor, Neurosurgery, Neurology, Neuroscience and Psychiatry

TITLE: Ketamine plus deep brain stimulation for severe treatment-resistant depression: identifying synergistic brain mechanisms to advance novel treatment discovery

ABSTRACT: Treatment resistant depression (TRD) represents a severe and disabling condition characterized by significant functional impairment, non-response to conventional antidepressants, and a high risk for suicide. Complementary mechanisms of action are attributed to successful treatment of TRD with deep brain stimulation (DBS) or ketamine. The proposed research will test if an EEG-derived biomarker of the antidepressant response to DBS also predicts outcomes following ketamine treatment. Results will provide critical rationale for a novel treatment approach that enhances DBS efficacy with a combined ketamine-DBS approach.

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