Dydrogesterone is a synthetic progesterone for menstrual cycle regulation, infertility treatment, prevention of miscarriage, and other conditions
Dydrogesterone
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
Synonyms
Didrogesterona
Didrogesterone
Dydrogesterona
Dydrogestérone
Dydrogesterone
Dydrogesteronum
Gestatron
Hydrogesterone
Hydrogestrone
Isopregnenone
Indication
Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
Associated Conditions
Infertility
Menstrual Distress (Dysmenorrhea)
Premenstrual Syndrome (PMS)
Recurrent Miscarriages
Spontaneous Abortions
Associated Therapies
Assisted Reproductive Technology therapy
Menstrual Regulation
NAV
Identification
Pharmacology
IndicationAssociated ConditionsAssociated TherapiesContraindications & Blackbox WarningsPharmacodynamicsMechanism of actionAbsorptionVolume of distributionProtein bindingMetabolismRoute of eliminationHalf-lifeClearanceAdverse EffectsToxicityPathwaysPharmacogenomic Effects/ADRs
Interactions
Products
Categories
Chemical Identifiers
References
Clinical Trials
Pharmacoeconomics
Properties
Spectra
Targets (1)
Enzymes (1)
Dydrogesterone
Star2
Summary
Dydrogesterone is a synthetic progesterone for menstrual cycle regulation, infertility treatment, prevention of miscarriage, and other conditions.
Generic NameDydrogesteroneDrugBank Accession NumberDB00378Background
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
TypeSmall MoleculeGroupsApproved, Investigational, WithdrawnStructure

3D
Similar Structures
WeightAverage: 312.4458
Monoisotopic: 312.20893014Chemical FormulaC21H28O2Synonyms
Didrogesterona
Didrogesterone
Dydrogesterona
Dydrogestérone
Dydrogesterone
Dydrogesteronum
Gestatron
Hydrogesterone
Hydrogestrone
Isopregnenone
External IDs
NSC-92336
PHARMACOLOGY
Indication
Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
Build, train, & validate predictive machine-learning models with structured datasets.
SEE HOW
Associated Conditions
Infertility
Menstrual Distress (Dysmenorrhea)
Premenstrual Syndrome (PMS)
Recurrent Miscarriages
Spontaneous Abortions
Associated Therapies
Assisted Reproductive Technology therapy
Menstrual Regulation
Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug events & improve clinical decision support.
Pharmacodynamics
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disoMechanism of action
Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis
Mechanism of action
Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
Absorption
Rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%.
