1- Bast RC Jr, Feeney M, Lazarus H, Nadler LM, Colvin RB, et al. (1981) Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68: 1331-1337.
2- Tahmasebi F, Nath R, Sokolovsky N, Scaffidi J, Boley J, et al. (2018) Incidental Finding of Raised CA125: a Cause for Concern? Crit Care Obst Gyne Vol.5 No.1:3.
3- Bischof P (1993) What do we know about the origin of CA 125. Eur J Obstet Gynecol Reprod Biol 49: 93-98.
CA125 was first identified by Bast et al. in 1981. Bast and his team isolated the murine monoclonal antibody OC125, which recognises an epitope on a molecule called CA125 – so-named because it is the 125th antibody produced against the ovarian cancer cell line.
CA125 is also known as mucin 16 because it is encoded by the MUC16 gene, located on chromosome 19.
CA125 levels can increase in both physiological and pathological conditions.
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