Topic: "Multiscale Modeling of Biomolecular Networks"
Systems biology aims to build a working model of cells by first mapping the network of interactions among intracellular proteins and other biomolecules. While highly successful, this network-based view of cells often treats biomolecules and their interactions as nodes and edges, with little atomic detail. Such detail are important because atomic-level changes in the molecular circuitry can lead to large differences in cell behavior, as often happens in evolution and disease.
Here, recent work is presented on constructing genome-scale structural models of nodes and edges within protein-protein interaction networks, in order to probe design principles of proteins and protein networks at multiple scales. The intention is to show that this multiscale structural systems biology approach provides useful insights into evolution and species interaction, cellular complexity, and human disease.
