Embark on an enlightening journey through the nuanced landscape of Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs), a class of medications used in the treatment of depression, anxiety, and chronic pain.
In this video, Dr Sanil Rege, Consultant Psychiatrist, goes beyond the surface to dissect the intricate mechanisms of SNRIs, revealing how they enhance cognition, affect emotions and alleviate pain by increasing the levels of serotonin and noradrenaline (norepinephrine) in the brain's synaptic cleft.
Key Moments:
0:00 Introduction to SNRIs
1:16 SNRI Effects on Dopaminergic and Noradrenergic Pathways
4:17 Why Desvenlafaxine and Duloxetine can help in severe forms of depression
4:43 Role of Noradrenaline in pain and its relevance to the choice of SNRI
5:22 Why does Venlafaxine have one of the most severe withdrawal symptoms?
However, not all SNRIs are the same. This analysis uncovers the distinct pharmacological profiles of venlafaxine, desvenlafaxine, duloxetine, milnacipran, and levomilnacipran, showcasing their varying affinities for serotonin (SERT) and noradrenaline (NAT) transporters.
These differences are not just chemical nuances; they have significant implications for clinical practice, influencing everything from dosing strategies to side effect management.
For instance, we explore how venlafaxine acts as an SSRI at lower doses and requires careful blood pressure monitoring at higher doses due to its potentiation of noradrenaline.
The video also sheds light on the role of SNRIs in pain management, particularly in conditions like fibromyalgia and diabetic neuropathy, where their ability to modulate noradrenaline levels offers substantial relief.
Furthermore, we address the challenges and considerations of SNRI withdrawal, comparing the nuances of venlafaxine and paroxetine withdrawal experiences due to their unique pharmacodynamic properties.
Join us as we navigate the complex but fascinating world of SNRIs, offering insights into their mechanisms, clinical applications, and the critical role they play in improving mental health and quality of life for individuals dealing with depression, anxiety, and chronic pain. This comprehensive guide is an invaluable resource for healthcare professionals, students, and anyone interested in the science behind these medications.
#SNRIsExplained #psychiatry #MentalHealthAwareness
#DepressionTreatment #AnxietyRelief
#ChronicPainManagement #SerotoninNoradrenaline #PharmacologyInsights #Venlafaxine #Duloxetine #Milnacipran #Levomilnacipran #MedicationEducation
#NeurotransmittersUnveiled
#PainReliefSolutions
#SNRIWithdrawal
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