Melina Elpi Marmarelis, MD, University of Pennsylvania, Philadelphia, PA, discusses the efficacy and safety of combining bevacizumab with atezolizumab and platinum-based chemotherapy in extensive-stage small-cell lung cancer (ES-SCLC) patients from Japan and China. The BEAT-SC trial showed that adding bevacizumab to the regimen significantly increased progression-free survival (PFS) compared to placebo. However, the first interim analysis for overall survival (OS) did not show a significant improvement. The combination was well-tolerated, with similar treatment-related adverse events between groups. Further OS follow-up is ongoing. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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