New Research in Nature reveals that fat cells retain a memory of obesity and that this has consequences on metabolic health and weight-regain. It seems like a pessimistic story, but there is hope. These data raise interesting questions like, if you maintain weight loss for longer, does it become easier to stay lean? What cells, other than fat cells, retain an epigenetic memory of past metabolic insults? We will dive into the data and stimulate your mind!
Chapters
0:00 – Fat Cells Retain an Epigenetic
0:49 – Yo-Yo Diet Effect
1:27 – Obesity Induces Epigenetic Changes in Humans
2:59 – Methods, snRNA-seq, Lasers
3:58 – Confirming the Results in Models of Obesity
4:53 – Epigenetics Analogy
6:03 – Confirming the Results in Models of Obesity
7:07 – My Main 3 Take-Aways
Hinte et al. Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature, 2024. PMID: 39558077
"Putting the Metabolism Back in Medicine" Initiative
I’m teaming up with ExamKrackers to help “Put the Metabolism Back in Medicine” by providing free MCAT-style passages based on papers covered in my videos. Share these with students who want to become doctors or attempt the questions yourself for fun!
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#obesity #epigenetics #metabolichealth #metabolism #nutritiontips #fatloss #staycurious
