Our treatment specialist and founder of ATMC, Lyle Murphy, answers your biggest concerns about the second generation antipsychotic drug Clozapine.


Clozaril is the brand name for the active ingredient, clozapine. Other brand names include Clopine, Clozapine Synthon, and FazaClo.



Q&A From you!

00:00 - Intro
00:20 - Why do so many doctors feel that Clozapine is the most effective medication for schizophrenia?
00:58 - Is clozapine a mood stabilizer?
01:21 - What are the worst side effects of clozapine?
03:13 - Why is clozapine called an atypical antipsychotic and not a benzodiazepine?
04:19 - Can clozapine cause tremors?
05:11 - What's next for the schizophrenic when clozapine fails? Doctors seem to always have another one ready?
06:04 - Could clozapine affect one's cognitive abilities/IQ?
08:31 - Is Clozapine worth the risk for those suffering from severe schizophrenia, considering how dangerous some of the side effects are?
10:07 - What antipsychotic is a good alternative to clozapine if you have to have something?
12:24 - Why would someone be prescribed a "therapeutic" dose of clozapine?
12:53 - Is olanzapine a better antipsychotic than clozapine if you worry about your physical health most?
15:20 - Which is less likely to cause tardive dyskinesia, olanzapine 2.5mg or clozapine 25mg?
15:55 - How long do antipsychotics withdrawal symptoms last from 2 months from 100 mg of Clozapine?
17:40 - What are the chances of a low dose (25mg) of clozapine causing tardive dyskinesia?
18:09 - Does a significant weight loss change the efficacy of clozapine?
19:04 - Can hypomotility caused by clozapine affect the absorption and efficacy of it?
20:32 - Will fasting for 24 hours affect the absorption of clozapine and cause a problem?
24:25 - ATMC

Careful Clozaril withdrawal can minimize the potential for rebound psychosis and cholinergic crises. Clozaril belongs to a class of drugs called SGA’s or second-generation antipsychotics.
Used in the treatment of certain mental conditions such as schizophrenia and psychosis, Clozaril is often prescribed only AFTER other antipsychotics did not work or caused severe side effects.
Alternative to Meds has been the expert on antipsychotic withdrawal and Clozaril alternatives for over 15 years. We have published evidence regarding our success. Underlying issues can in many cases be addressed in much less toxic ways. It is possible that some medical conditions could have been overlooked. Commonly some or all of the original contributing factors have improved or changed, and the diagnosis one was given may no longer lead to recovery.


What Is Clozaril (clozapine) Used For?


Clozaril is used in the treatment of certain mental disorders, where other (usually at least two) other antipsychotic medications have not worked, or where the side effects were too harsh and could not be tolerated by the patient. A candidate for a prescription of Clozaril could be someone diagnosed with conditions such as:

Treatment-resistant schizophrenia.
Treatment-resistant schizoaffective disorder with a known risk for suicide.
Please note that elderly patients with dementia-related psychosis should NOT be prescribed Clozaril (or other antipsychotic medications) due to the increased risk of death.


Discontinuing/Quitting Clozaril (clozapine)
There are circumstances where immediate withdrawal of Clozaril is medically needed as a life-saving intervention. These include potentially life-threatening adverse reactions to the drug which are delineated in detail under the adverse effects section, for instance, cardiovascular compromise, risk of stroke, signs of tardive dyskinesia, and other severe reactions.

In the majority of cases, gradual Clozaril tapering methods are recommended for coming off the drug.

Always seek medical guidance and direction from your doctor before making changes to medications.

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