Christopher Melani, MD, National Institutes of Health, Bethesda, MD, comments on the success of Bruton’s tyrosine kinase (BTK) inhibitors in the treatment of non-Hodgkin lymphoma (NHL), particularly relapsed/refractory mantle cell lymphoma (R/R MCL). Dr Melani begins by discussing the safety and efficacy of approved BTK inhibitors in R/R MCL, and compares the progression-free survival (PFS) data for these monotherapies to the combination of venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR; NCT03223610). Dr Melani explains the promising results from the ViPOR study and shares some perspectives on the future of BTK inhibitors in MCL. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.
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