This Harvard Medical School Continuing Education video examines these key questions: How are adverse pregnancy outcomes linked to cardiovascular disease? Does pregnancy history play a role in preventative cardiovascular care for women?
Dr. Michael Honigberg, MD, a cardiologist at Massachusetts General Hospital, reviews adverse pregnancy outcomes (APOs) and their association with chronic hypertension, coronary artery disease, heart failure, aortic stenosis and mitrial regurgitation. Guidelines for preventive cardiovascular care for women with APOs are identified.
This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content.
00:00 | Introduction
00:40 | Definitions of adverse pregnancy outcomes (APOs)
01:47 | Associations between APOs and cardiovascular disease
04:48 | Hypertensive disorders in pregnancy and genetic risk factors
05:24 | Potential mechanisms linking APOs to cardiovascular disease
06:02 | Implications for preventive care
References:
Wu P, Park K, Gulati M. The Fourth Trimester: Pregnancy as a Predictor of Cardiovascular Disease. Eur Cardiol. 2021;16:e31. doi:10.15420/ecr.2021.18.
Catov JM, McNeil RB, Marsh DJ, et al. Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery. J Am Heart Assoc. 2021;10:e017216. doi:10.1161/JAHA.120.017216.
Honigberg MC, Zekavat SM, Aragam K, et al. Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy. J Am Coll Cardiol. 2019;74(22):2743-2754. doi:10.1016/j.jacc.2019.09.052.
Bokslag A, Teunissen PW, Franssen C, et al. Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life. Am J Obstet Gynecol. 2017;216(5):523.e1-523.e7. doi:10.1016/j.ajog.2017.02.015.
Søndergaard MM, Hlatky MA, Stefanick ML, et al. Association of Adverse Pregnancy Outcomes With Risk of Atherosclerotic Cardiovascular Disease in Postmenopausal Women. JAMA Cardiol. 2020;5(12):1390-1398. doi:10.1001/jamacardio.2020.4097.
Honigberg MC, Zekavat SM, Aragam K, et al. Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy. J Am Coll Cardiol. 2019;74(22):2743-2754. doi:10.1016/j.jacc.2019.09.052.
Honigberg MC, Chaffin M, Aragam K, et al. Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy. Circulation. 2020;142:711–713. doi:10.1161/CIRCULATIONAHA.120.047936.
Parikh NI, Gonzalez JM, Anderson CAM, et al. Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association. Circulation. 2021;143:e902–e916. doi:10.1161/CIR.0000000000000961. I can
Cho L, Davis M, Elgendy I, et al. Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75(20):2602-2618. doi:10.1016/j.jacc.2020.03.060.
Notice: At this time, the content in this video is not accredited.
