To design clinical trials, efficiency, ethics, cost effectively, research duration and sample size calculations are the key things to remember. This review highlights the statistical issues to estimate the sample size requirement. It elaborates the theory, methods and steps for the sample size calculation in randomized controlled trials. It also emphasizes that researchers should consider the study design first and then choose appropriate sample size calculation method.
How To Calculate the Sample Size for Randomised Controlled Trials
Formulas for sample size calculation differ depending on the type of study design and the studies outcome(s). These calculations are particularly of interest in the design of randomised controlled trials (RCTs). In general, sample size calculations are performed based on the primary outcome of the study.
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Sample Size Calculations for Randomized Controlled Trials (RCT)
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