Processing of Amyloid Precursor Protein (APP)

APP can be processed either by the non-amyloidogenic pathway or by the amyloidogenic pathway. Processing by the amyloidogenic pathway results in beta-amyloid fragments that could aggregrate into plaques, a pathological hallmark of Alzheimer's disease.

Reference:
Selkoe DJ, Schenk D (2003) Alzheimer’s disease: Molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43:545-584.
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