Understandings:
In animal studies, the therapeutic index is the lethal dose of a drug for 50% of the population (LD50) divided by the minimum effective dose for 50% of the population (ED50).
In humans, the therapeutic index is the toxic dose of a drug for 50% of the population (TD50) divided by the minimum effective dose for 50% of the population (ED50).
Applications and skills:
Discussion of experimental foundations for therapeutic index and therapeutic window through both animal and human studies.

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