Laura Samples, MD, University of Washington, Seattle, WA, shares the findings of a retrospective study investigating outcomes of venetoclax (Ven)-based therapy for patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) who have progressive disease or intolerance following exposure to covalent BTK inhibitors (BTKi's). The study raises questions about whether Ven-based fixed-duration therapy is optimal for patients who progress on BTKi's. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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