Elizabeth Leroux, MD, FRCP, University of Calgary, Calgary, Canada, discusses the potential relationship between metabolic factors and migraine, with emerging evidence suggesting that migraine may be a protective reaction of the brain to a mismatch between excessive energy demand and insufficient energy availability. Dr Leroux highlights that almost all triggers leading to migraine attacks are related to oxidative stress, and it is necessary to consider metabolic factors as key players in the triggering of the cascade that leads to the onset of migraine. Additionally, Dr Leroux suggests that a poorer response to calcitonin gene-related peptide (CGRP) blockade is often observed in patients with obesity, vascular disorders, and traumatic childhood events. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

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