Boris Johnson will be quizzed by the Liaison Committee from 3.30pm.
Committee members include senior MPs Sarah Champion, Tobias Ellwood, Yvette Cooper and Jeremy Hunt.
They will question the Prime Minister on the vaccine rollout.
Boris Johnson is expected to speak to his EU counterparts this week as a row over Covid vaccine supplies continues.
EU leaders will hold a virtual meeting on Thursday to discuss a ban on Oxford-AstraZeneca vaccine exports to the UK - but the PM aims to put the UK's case in one-on-one phone calls before that.
The European Commission president says the EU can "forbid" vaccines made on the continent being sent to the UK.
The PM said the vaccination rollout requires "international cooperation".
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