Deadpool has a very unique skill rotation. After playing with him for a few hours you start to realize you don't just want to spam out a 5 4 3 2 1 kind of rotation. I was starting fight getting hit to get t2 passive buff oping with proc on 5 2 1 3 cancel 3 just as he cuts the grenades reset 4 2 1 3 cancel 3 just as he cuts grenades reset. This was the best way to keep his skill rotation with very little gaps and hitting damage proc on best skills of 5 & 4.
Remember always try to randomly get hit when you can to set up his t2 passive. This rotation will change with T3 but for now I feel as if this is the optimal way to do max damage.
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