In this video I have explained all the points related to regulation of pyruvate dehydrogenase enzyme complex. Pyruvate dehydrogenase enzyme complex is also written as PDH complex or simple PDC. It has feedback regulation, allosteric modulation, covalent modification mediated by insulin and glucagon. In fasting condition its activity will decrease and in fed condition its activity will increase. NADH, acetyl CoA have a negative effect on PDH, ADP and pyruvate and Ca2+ will have a positive effect on PDH complex.
My video link for pyruvate dehydrogenase complex enzyme structure and function is as below.
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Pyruvate Dehydrogenase Complex Regulation
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