This study explored the effects of elderberry extract on testosterone levels in rats experiencing testosterone deficiency syndrome (TDS). The researchers focused on how elderberry extract affected key enzymes involved in testosterone production and metabolism. They found that the extract increased total testosterone levels by 113.4% in the low-dose group, 219.3% in the mid-dose group, and 267.1% in the high-dose group compared to the control group. 1 Importantly, the high-dose group's testosterone levels were restored to levels similar to those of young rats. 2 The extract also increased free testosterone (the active form that's not bound to proteins) and improved sperm motility. 3 Furthermore, the researchers found no negative effects on prostate health, liver function, or kidney function, suggesting that elderberry extract could be a safe and effective natural approach for managing testosterone deficiency.
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Kim J, An J, Song Y, Jang M, Kong H, Kim S. Effect of Elderberry (Sambucus nigra L.) Extract Intake on Normalizing Testosterone Concentration in Testosterone Deficiency Syndrome Rat Model Through Regulation of 17β-HSD, 5α-Reductase, and CYP19A1 Expression. Nutrients. 2024; 16(23):4169. [ Ссылка ]
testosterone deficiency syndrome, elderberry, Sambucus nigra L., total testosterone, free testosterone, testosterone synthesis, Leydig cell, mitochondrial dysfunction, reactive oxygen species, phytotherapy, rutin, fructose-leucine, sperm motility, prostate-specific antigen, alanine aminotransferase, aspartate aminotransferase, creatinine, 3β-HSD, CYP17A1, 17β-HSD, 5α-reductase, CYP19A1, aromatase, ELISA, qRT-PCR
