This case series includes 12 patients who were referred to the Keck Medical Center at USC for complications from gastroesophageal reflux from June 2022 to October 2022. The upper GI endoscopy revealed that each patient had NDBE and the tissue was sent for TissueCypher testing to determine the patient’s individualized risk of progression. Dr. John Lipham, Professor of Clinical Surgery & Chief of Upper GI and General Surgery at Keck Medicine of USC, weighs in.

Background
Barrett’s esophagus (BE) is a precancerous condition that is caused by chronic acid reflux. For severe acid reflux, surgical options are available that can repair the esophageal sphincter to reduce or eliminate acid reflux.

Expert foregut surgery centers often encounter patients that have developed BE. While the majority are at low risk of progression to esophageal cancer, some are at high risk and should be treated with endoscopic eradication therapy (EET) or closely surveilled to detect dysplasia and cancer at early, treatable stages.

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