This sqadia.com short video clip is the brief explanation of Atheroma Formation.
Endothelial injury allows entry of cholesterol-rich, low-density lipoproteins into the intima Plasma proteins and lipids diffuse into arterial intima.
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Monocytes bind newly expressed receptors and migrate into intima, differentiating into macrophages. These macrophages take up oxidized LDL to form foam cells.
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When they die, release of the cellular contents of these cells forms extracellular lipid pools. Smooth muscle cells move to intima, producing collagens in an attempt to stabilize the growing lesion.
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