Title: Tissue microstructure underlying cortical folding in the human fetal brain.
Session: Oral Session
Speaker: Sian Wilson
Abstract: The structural scaffolding of the human brain is assembled during the fetal period, through a series of rapid, dynamic, and intersecting processes. The third trimester in particular, is characterised by the emergence of complex cortical folding patterns, the development of white matter connections and dissipation of transient compartments such as the subplate (1). Although it is hypothesised that cortical gyrification is influenced by both underlying fibre connectivity (2) and cytoarchitecture (3), in utero studies of their co-maturation in the human brain have not previously been possible. Using state-of-the-art high resolution multi-shell diffusion-weighted imaging (DWI) collected as part of the Developing Human Connectome Project (dHCP), we calculate vertex-wise correlations between sulcal depth and microstructural measures in the subplate and cortical plate across gestational age, exploring this relationship both at the population level and within subjects.

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