Lorenzo Falchi, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the rationale and results from two arms of the EPCORE NHL-2 Phase I/II trial (NCT04663347) evaluating the safety and efficacy of subcutaneous epcoritamab in combination with rituximab and lenalidomide in patients with newly diagnosed and relapsed/refractory (R/R) follicular lymphoma (FL). Both trial arms reported promising results in terms of both efficacy and safety, with low-grade, manageable adverse events (AEs). Dr Falchi then discusses where this combination therapy may fit in the treatment regimen of FL, arguing that whilst in the R/R setting, this combination is likely to become a new standard of care (SOC), more data is needed to assess the benefit of this therapy in the frontline setting. This interview took place at the 64th ASH Annual Meeting and Exposition Congress held in New Orleans, LA.
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