Tuberculosis is the second leading cause of death by infectious disease in the world right now. Number one has only existed for a year and a half.

While much more is known about the former, including effective treatments, the world still struggles to alleviate its burden. Part of the problem is how new technology, such as IGRA and NAAT, made pathways more complex, even if more effective.

In this video, I’ll review the evidence and try to clear up everything you need to know about latent TB: as a practitioner or a student. In my years of practice in Brazil, and even in the United States, I often saw people with suspicion for latent or active TB. Distilling the main concepts and relevant evidence for it will hopefully make it easier for you as well.
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References:
-Theme song: In the Hall of the Mountain King - Edvard Grieg
-tb deaths [ Ссылка ]
-UK guidelines, world incidence map [ Ссылка ]
-latent TB to active risk ‘82 study [ Ссылка ]
-latent tb cdc [ Ссылка ]
-tst image from cdc [ Ссылка ]
-tst induration [ Ссылка ]
-isoniazide hepatitis risk [ Ссылка ]
-discontinue TB precautions cdc.gov/mmwr/preview/mmwrhtml/rr5417a1.htm
-IGRA principles [ Ссылка ]
-dx latent TB adults [ Ссылка ]
-WHO 2014 dx TB in children [ Ссылка ]
-WHO 2006 dx TB children [ Ссылка ]#
-study rifampin isoniazide [ Ссылка ]
-study rifapentine isoniazide [ Ссылка ]
-study rifampin solo [ Ссылка ]
-childhood exposure, risk of invasive TB [ Ссылка ]-
-WHO latent TB infection [ Ссылка ]
-TST cutoffs paper [ Ссылка ]
-simplify gif [ Ссылка ]
-GIF indecisive [ Ссылка ]
-GIF its a lot [ Ссылка ]
-GIF mix n match [ Ссылка ]
-eradication smallpox [ Ссылка ]
-eradication polio [ Ссылка ]
-kid thumbs up gif [ Ссылка ]
-boo gif [ Ссылка ]

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