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In this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research methodologies, and regulatory hurdles like the FDA’s stance on aging. They address emerging ideas such as leveraging AI for aging research, the importance of lifestyle factors like diet and sleep, and the need for actionable biomarkers. The session is a candid exchange of expert opinions, tackling scientific controversies and practical strategies for healthy aging.

00:02:33 - What are the potential side effects of Rapamycin, such as on blood lipids or blood sugar?
00:04:22 - How can diet and lifestyle changes enhance cognitive performance?
00:06:09 - What is your favorite biomarker for studying human aging?
00:09:46 - Why do you recommend against taking many supplements at once?
00:13:52 - Is there legitimacy to the idea that aging accelerates at certain ages, like 44 and 60, and does this influence the timing of interventions like Rapamycin?
00:18:34 - When do you think drugs targeting healthspan or lifespan will get regulatory approval for general use?
00:21:38 - Does the FDA's classification of aging as not a disease hinder progress for gero-therapeutics?
00:24:25 - Why are autoimmune diseases becoming more common, and could Rapamycin help with such conditions?
00:27:05 - Is there something you two strongly disagree on regarding aging science or interventions?
00:30:46 - Does NAD+ supplementation meaningfully affect aging, and how should it be delivered?
00:33:32 - What other factors besides diet, exercise, and sleep are vital for functional, healthy aging?
00:37:13 - How important are circadian rhythms and sunlight exposure for longevity, and how do you incorporate this into your routine?
00:39:19 - How should one approach the dosing and timing of Rapamycin for safety and efficacy?
00:43:45 - What does it take to confidently call a molecule a gero-protective agent?
00:46:08 - How many of the hallmarks of aging does Rapamycin target, and are its effects direct or indirect?
00:51:57 - Can real-world evidence collected outside clinical trials convincingly demonstrate gero-protective effects?
00:54:16 - What is the significance of heart rate variability (HRV) as a biomarker, and how can it be improved?
00:56:00 - Is olive oil genuinely a gero-protective substance or is its health value overstated?
00:57:40 - How important are telomeres for aging, and are they useful as biomarkers?
00:58:04 - Are there ongoing or planned human clinical trials for Rapamycin?
00:59:37 - Does combining Rapamycin with fasting lower mTOR2 activity excessively?
01:00:51 - How does Rapamycin affect exercise performance and recovery?
01:02:14 - Do you consider melatonin a gero-protective molecule?
01:04:33 - How should the public interpret studies with flawed methodologies on aging-related supplements or interventions?
01:08:57 - Can community-based studies or observational data reliably prove gero-protection?
01:10:55 - How can interventions target biological networks rather than just single aging pathways?
01:13:30 - What criteria should the public use when evaluating the credibility of longevity products?
01:16:47 - Which conferences or events would you recommend for learning about aging and longevity science?

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

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