Dean Fennell, FRCP, PhD, University of Leicester, Leicester, UK, discusses results from the Phase III BEAT-meso trial (NCT03762018) of atezolizumab with bevacizumab and standard chemotherapy as a first-line treatment for advanced pleural mesothelioma (PM). An increase in median progression free survival (PFS) was seen with atezolizumab and whilst this did not translate into a significant increase in overall survival (OS), it did push the median OS to over 20 months, which has not been achieved in previous trials on advanced PM. Additionally, atezolizumab was very effective in non-epithelioid cases. This study reflects the promising movement towards combination of chemotherapy and immunotherapy. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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