Chao Sun (Max Planck Institute for Brain Research)
- Subcellular Stoichiometry of Neuronal Proteasome Assembly
Nan Bai (Amgen)
- Modeling CRL4A ligase complex to predict target protein ubiquitination induced by CRBN-recruiting PROTACs
Xiuxiu Lu (NCI/NIH)
- Structure-guided hRpn13-targeting bifunctional molecules as chemical probes of hRpn13 dysfunction
Agatheeswaran Subramaniam (Lund University)
- UM171 promotes ex vivo expansion of hematopoietic stem cells by targeting the epigenetic modulator CoREST for degradation
Daniel Zaidman (University of Cambridge)
- PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
About Dana-Farber Targeted Protein Degradation Webinar Series:
Targeted protein degradation (TPD) is a rapidly growing interdisciplinary area of research of both basic science and translational importance. TPD is primarily concerned with the development of agents that induce degradation of protein targets. The precise removal of the target is often linked to a therapeutically beneficial phenotype, making TPD of high interest for drug discovery and development.
This webinar series brings together the community of scientists interested in TPD and rapid dissemination of knowledge and best practices. To learn more and join the future webinars please visit:
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