Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, outlines findings from a UK-wide cohort which evaluated the efficacy of isatuximab with pomalidomide and dexamethasone as a fourth-line treatment for frail patients with relapsed/refractory (R/R) multiple myeloma. Overall, whilst the study found clinical benefits of this novel combinational therapy in frail patients, there were also higher rates of treatment discontinuation, a higher toxicity burden and a lower progression-free survival (PFS) in frail patients when compared to fitter patients. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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