Many growth factors, hormones, cytokines, and nutrients activate the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway. The PI3K-AKT signaling is involved in the control of numerous critical cellular processes such as apoptosis, cell proliferation, and the cell cycle. Dysregulated PI3K/AKT signaling is involved in the pathophysiology of a range of diseases including cancer, cardiovascular disease, type 2 diabetes, and others.
Learn about the proteins involved in the pathway and how the mutation of AKT1 at E17K contributes to tumorigenesis.
Bio-Rad offers a range of highly validated PrecisionAb Antibodies to study this signaling pathway successfully. You can also download a copy of a poster for this pathway and others such as EGF R, mTOR, NF-kB, and more.
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