I demonstrate how medication absorption and distribution can be affected by pH and their ability to be ionized or non-ionized. In this real experiment, I use an ionizable dye to simulate how acidifying the aqueous phase can drive a drug molecule into the lipid phase (octanol). This represents how a drug can move across an epithelial cell barrier if it is made non-ionized (neutral) by altering pH. In the real world, medications and foods can affect gastric pH, and therefore drug absorption. Moreover, the demonstration can be used to explain how drugs can get trapped in milk of nursing mothers (difference in milk pH vs. blood).

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