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Why Do You Need to Taper Off Trazodone?
Trazodone is classed as a SARI antidepressant (serotonin antagonist reuptake inhibitor). Trazodone is solely approved to be prescribed for depression but is more frequently used off-label for a wide range of other uses. It is concerning that all antidepressants (including trazodone) carry a black box warning for the heightened risk of suicide.

SARI drugs are thought to block serotonin from adhering to 5-HT2 receptors. However, trazodone at low doses acts as a serotonin agonist (mimics serotonin) and only becomes a serotonin antagonist (blocks serotonin) at high doses. Low doses of trazodone are typically prescribed for insomnia, and higher doses are typically used in the treatment of depression. After neurochemical expression, serotonin would normally be broken down and recycled. Blocking the reabsorption of neurochemicals causes these suspended molecules to eventually degrade and become useless waste products. As with all antidepressant agents that are serotonergic, a deficit in vital levels of serotonin will often result, leading to worsening depression over time. SARI drugs such as trazodone are also thought to alter or block dopamine, histamine, acetylcholine, norepinephrine, and other neurochemicals, and disrupt the normal distribution of these natural neurochemicals in the brain and along the nerve channels of the CNS.

Before starting or stopping a drug such as trazodone it is recommended to adequately research and understand as much as possible to enable informed decisions. Be prepared, and ready to seek medical help if the drug you were prescribed isn’t helping, or if your symptoms are worsening. Below is a body of information that may help to provide the most searched for answers about trazodone side effects, trazodone withdrawal symptoms, and other relevant data.

Trazodone Alternatives Treatment
The Alternative to Meds Center specializes in providing the types of treatment that are designed to help a person transition to a drug-free and symptom-free daily life. Trazodone is frequently prescribed off-label to treat insomnia, OCD, anxiety disorders, pain, bulimia, and even to mitigate the side effects of other medications. That is a partial list of off-label uses for trazodone. Trazodone is only FDA-approved for the treatment of depression.

According to a 2017 study on the effects of antidepressants for treating insomnia, the results showed that while trazodone was more effective than some other antidepressants at improving sleep, it may lead to other problems such as over-sedation, REM sleep behavior disorder, and others.

Trazodone can bring on a condition called priapism, (persistent, painful penile erection) requiring urgent surgery to save the organ.26

At lower doses, Trazodone acts as a hypnotic, and at higher doses, as an antidepressant by blocking the serotonin pathway. As noted on the FDA label, Trazodone has been given a black box suicide warning and can also induce the potentially lethal condition called serotonin syndrome, so these risks can be quite dangerous. As far as other drugs that may be recommended as “alternative choices,” they have just as high a risk of being ineffective and causing adverse or unwanted side effects. Some doctors who are not aware of better alternatives may even suggest electroconvulsive therapy. There are safer trazodone alternatives that do not carry such risks, and some of these will be discussed in more detail as you continue reading.

At Alternative to Meds Center, we aim to address each person’s unique profile and the symptoms they wish to be rid of with a customized holistic trazodone tapering and alternatives program to achieve maximum relief of symptoms, without side effects from the treatment.

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