The functional role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions, here we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former can grant us the possibility to map functional neuroimaging on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. We will also introduce our freely available Atlas of White Matter Function that enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for explorations in the domain of cognition.

Articles discussed
Thiebaut de Schotten et al. Nature Comm. 2020 [ Ссылка ]
Foulon et al. Gigascience 2018 [ Ссылка ]

Software employed
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Data available at
The two sets of component maps and the atlas of white matter function (original and replication) are available at [ Ссылка ]. The atlas of white matter function is also available at A–C terms: [ Ссылка ]. D–H terms: [ Ссылка ]. I–N terms: [ Ссылка ]. O–R terms: [ Ссылка ]. S–U terms: [ Ссылка ]. V–Z terms: [ Ссылка ]. The raw dataset analysed in the current study is available at [ Ссылка ] (7 T diffusion data) and [ Ссылка ] (metanalytic functional MRI maps). In addition, processed data are available at [ Ссылка ] and [ Ссылка ]

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