In this episode - fibrotic non-specific interstitial pneumonia (or NSIP) - what does this diagnosis mean and how is is treated?

NSIP is a pattern that we can see on a chest CT scan or on a lung biopsy (on the pathology report). What does this mean for you as a patient or someone who cares for someone who has NSIP?

NSIP may be associated with inflammatory conditions affecting the body (i.e. connective tissue diseases, such as rheumatoid arthritis or others) or may occur without a known cause (and we call this situation idiopathic NSIP). We call NSIP fibrotic if there is lung scarring. If there is no fibrosis, sometime this may be referred to as just NSIP or "cellular" NSIP.

Treating NSIP is generally with anti-inflammatory medication as a first line, normally corticosteroids such as prednisolone. Sometimes this may not be enough, or we would want to use a lower dose of prednisolone, so we can introduce immunosuppressants, such as mycophenolate, as a second line. If despite these therapies, the NSIP fibrosis is still getting worse (progressive pulmonary fibrosis), antifibrotic treatments such as nintedanib may be added, in order to stabilize the condition as much as we can.

Obviously, the more treatments we add, the more careful we need to be about side effects. Routine blood monitoring is usually done with your healthcare team, and regular follow-up is essential.

Hope this info helps, although it's unlikely this one video will cover all the nuances in your case. Always check everything with your own healthcare team.

#NSIP #fibrotic #pulmonaryfibrosis

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The opinions presented on this channel are my own and do not constitute medical advice in specific cases. If you are watching/listening to this content as a patient, you must seek personalized advice from your own healthcare team (who can provide you with a consultation and appropriate treatment and advice. This information presented here may not apply in your case. If you are a health professional, please use your professional judgement when treating patients.

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