#RestingMembranePotential #ActionPotenial #Neurology #ActionPotentialinNeurons #Neurology

Action Potential in Neurons | Neurology | Dr Najeeb

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(0:00-9:05)
Defining Action Potential; explanation of Resting Membrane Potential (RMP); role of Na-K ATPase & K+ equilibrium potential.

(9:05-40:55)
Explanation of Action Potential:
Mechanism of action of Local Potential, Depolarization & Repolarization of membrane; role of voltage-gated Na & K channels; sub-threshold and threshold potential.

(40:57-57:49)
Explanation of Action Potential continued:
Propagation of local potential in the membrane/Creation of Action Potential.
Differences b/w Local Potential and Action Potential; mention of "All or none" principle.

(57:50-1:13:31)
Explanation of 'Refractory Period' in Action Potential; role of Activation & Inactivation gates of Na-channel.
Absolute and Relative Refractory Period (ARP & RRP).

(1:13:32-1:23:12)
Phenomena of "Accommodation" explained in neurons; Na-channels stuck in inactivation state; clinical co-relate with Hyperkalemia.
Difference b/w phenomena of Refractory period & Accommodation.

(1:23:13-1:30:19)
Neurotransmission; communication b/w neuronal cells; role of Neurotransmitters (NTs) and ligand-gated Na-channels.
Electrical transmission b/w cardiac cells; role of Na gap-junctions.
Types of stimulation: Mechanical, electrical and chemical.

(1:30:21-1:36:43)
Factors determining the velocity of AP in neuronal axons; diameter of neuronal axon, myelination of neuronal axon.

(1:36:44-1:54:26)
Transmission of AP across an Unmyelinated neuronal axon; in detail.

(1:54:27-2:12:44)
Mechanism of transmission of AP across a Myelinated neuronal axon; Schwann Cells; Saltatory Conduction.
Examples of slow and fast conduction of different sensations of the body; dull & sharp pain, tickling & temperature etc.

(2:12:45-2:24:39)
Comparison of structure of myelinated & unmyelinated axons;
Clinical Co-relate with phenomena of Myelination: Guillain Barre Syndrome & Multiple Sclerosis.

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