Sara M. Tolaney, MD, MPH, Dana-Farber Cancer Institute, Boston, MA, shares the final 10-year analysis of the Phase II APT (NCT00542451) trial investigating adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer. The primary endpoint was invasive disease-free survival (iDFS). The 7-year results saw an IDFS of 93%, a recurrence-free interval (RFI) of 97.5% with only four (1.0%) distant recurrences, and a 7-year overall survival (OS) of 95%. After a median follow-up of 10.2 years, 36 iDFS events were observed, consistent with a 10-year iDFS of 89.7%. 10-year iDFS was 90.2% and 88.5% for patients with HR-positive and HR-negative tumors at baseline, respectively. 10-year RFI was 96.8%, 10-year OS was 94.2% and 10-year BCSS was 99.1%. The novel biomarker assay HER2DX was also assessed, which was associated with long-term outcomes. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.
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