In London, England Lara searches for the Eye of Isis, now in the possession of Sophia Leigh, the head of a cosmetics corporation. Following the numerous failed assassination attempts by every last hitman who were hired by Sophia, Lara heads into the abandoned subway station, Aldwych, coming across several members of the Damned, former test subjects whom the corporation performed sick experiments on in order to achieve immortality and eternal youth for Sophia's personal gain. She learns that the deformed subjects of Sophia's failed experiments, presumed dead by the corporation, were dumped in the sewers. The leader of the Damned, Bob, offers to assist Lara in exchange for a bottle of embalming fluid from the Natural History Museum. Lara climbs through a ventilation shaft to Sophia's office where she is sitting with the artifact on her desk. Sophia suggests to Lara a job in an insulting and snooty manner, telling her that with her lifestyle she would be the perfect new face for her products. However, Lara throughs back her insulting offer by telling her that her human subjects she experimented on, are still alive. Lara naively requests that she hand over the artifact which of course, she refuses to do. Sophia takes the artifact and runs out the balcony and to the other building, and Lara who works her way up Sophia's building and across to the one she's on. Sophia attempts to kill her using the powers of the artifact, but Lara defeats her by shooting a fuse box connected to an electrical bridge that Sophia was standing on, after the battle causing her to get fatally electrocuted. After retrieving the "Eye of Isis" artifact, Lara sets off to final location to collect the final artifact, "Element 115" located in Nevada, USA.

Sophia Leigh was voice by British voice actress Judith Gibbins. The same voice actress who provided the voice Lara Croft in Tomb Raider 2 and Tomb Raider 3.

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