EMERGENCY NUMBERS if your pet has ingested Ibuprofen products:
1. www.poison.org – call 1-800-222-1222
2. www.aspca.org – call (888)-426-4435

Common brand names that have ibuprofen in them are: Advil, Midol, and Motrin.

I am going to focus on Advil in this video which normally comes in 200mg tabs or capsules. The problem is some have a sugar coat on them making it appetizing for our dogs to eat more than they normally would.
Ibuprofen is an anti-inflammatory drug used to alleviate inflammation and pain from wounds, migraines, body aches, and as a fever reducer if sick. This is for human consumption only. And won’t help these clinical signs in our dogs like it helps us!

There are specific Dog and Cat NSAIDS (Non-steroidal anti-inflammatories) you need to get from your veterinarian that were developed for pets and are safe for your pets. Called Rimadyl, Galliprant and more.

So what toxic effects does it have on your dog?
Ibuprofen has its main Toxic effects on dog’s gastrointestinal tract, Kidneys and Central nervous system in highest doses. But for those Pre-Vet students or pet parents out there mainly think Kidney failure when you think of Advil ingestion in dogs.
In the simplest explanation what ibuprofen does is it blocks vasodilatory prostaglandins which diminishes kidney blood flow and lead to acute Kidney failure.

So before you panic:
Lets get into some Practice Cases to give you an idea of how much Advil is toxic to your dog and let me tell you some case studies and reported doses to give you an idea of how much advil is toxic to your dog.
The Toxic effects with LOW toxic doses includes Vomiting, Diarrhea, Bloody Vomiting, Bloody diarrhea.
Toxic effects with HIGH toxic doses includes Acute kidney failure and CNS signs of seizure and comma.

OK SO in a study done they found that
Toxicity can be seen with a dose of 8mg/kg/day for 30 days in a row.
- Just Gastric ulcers and intestinal inflammation – the dogs did not die.
16mg/kg/day for 6 weeks – vomiting, diarrhea, and intestinal inflammation , still dogs did not die.
Acute Ibuprofen overdose in dogs and cats:
Single acute over dose of 25mg/kg can cause vomiting in dogs.
At doses greater than 175mg/kg the risk of acute kidney failure increases.
Doses greater than 400mg/kg – we see central nervous system signs like seizures and comma and even death.


Treatment:
IBUPROFEN ingestion is TIME SENSITIVE to toxicity levels and prognosis of your dog. This requires immediate attention from your veterinarian to perform detox procedures.

Your vet will want to get bloodwork to obtain baseline kidney values which are BUN or Blood urea nitrogen and creatinine levels.

Dogs with recent exposure of 2 hours after ingestion , that are not showing clinical signs like vomiting your veterinarian will induce vomiting to try to get the pills out so they can not release more toxin.

Animals already exhibiting neurological signs are not candidates to make them vomit. In these cases gastric lavage, enterogastric lavage may be useful. Administering multiple doses of activated charcoal every 6 to 24 hours in all affected animals because ibuprofen undergoes enterohepatic recirculation.

Other treatments of detox will be directed at preventing or treating other possible complications of acute or chronic exposure.
For gastrointestinal upset and ulcerations Gi protectants are used like sucralfate.
It is not recommended to use Peto-Bismol since there is an interaction of the Salicylates with ibuprofen.

Treatment for doses that may have caused renal failure:
IV diuresis is recommended. If kidney values are normal at 48 hours reduce fluid therapy to maintenance rates and discontinue after another e24 hours.

Your veterinarian will want to do blood work to obtain baseline kidney values, concentrating on BUN and Creatinine levels. Serial urinalysis can be monitored for tubular casts, which may be seen as little as 18 hours post ingestion.

If patients come in with seizures treat with barbituates or diazepam as needed. Comatose animals need supportivce care and monitoring and maintenance of body temperature and respiration. These animals are in severe critical condition.

Overall, Ibuprofen ingestion in dogs and cats is a potentially life threatening problem in animals. The prognosis which we learned today depends on how much they have ingested and the severity of the clinical signs. Emergent and aggressive decontamination and IV Supportive care are essential to improve the chances of recovery.

I hope you guys enjoyed this video and learned something new today.

Please share this video with any of your pet owning friends out there and new puppy or dog owners especially.

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