Ryan Jacobs, MD, Atrium Health Levine Cancer Institute, Charlotte, NC, discusses the impact of the recent approval of pirtobrutinib, a third-generation BTK inhibitor (BTKi), as a third-line treatment for chronic lymphocytic leukemia (CLL). Dr Jacobs highlights that this was a setting in which patients lacked safe and effective treatment options. Pirtobrutinib is well-tolerated and effective compared to other agents tested in this space, such as duvelisib, a PI3 kinase inhibitor. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

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