antiemetic drugs pharmacology, ondansetron pharmacology, zofran pharmacology, ondansetron mechanism of action, ondansetron side effects, ondansetron contraindications, pharmacology made easy,
▪ Antiemetics are a group of medications that are used to treat nausea and vomiting. These include ondansetron, metoclopramide, aprepitant, prochlorperazine, and promethazine, as well as antihistamines like diphenhydramine, and cannabinoids, such as dronabinol.
▪ Ondansetron (Zofran), which can be administered orally, intravenously, and intramuscularly. Once administered, ondansetron acts as a 5-HT3 receptor antagonist peripherally by decreasing vagal nerve stimulation, but it is also a very powerful central acting antiemetic blocking an area in the brain called chemoreceptor trigger zone, or CTZ.
▪ Ondansetron is primarily used to control nausea and vomiting after surgical anesthesia, as well in individuals undergoing chemotherapy or radiotherapy.
▪ . Ondansetron can cause headaches, gastrointestinal disturbances like constipation, and can prolong the QT interval, leading to arrhythmias.
A life-threatening side effect of ondansetron is serotonin syndrome, which is caused by serotonin accumulation that results in overstimulation of the nervous system.
▪ As far as contraindications go, ondansetron should be avoided in clients with risk factors for QT prolongation or in combination with other medications that increase serotonin levels, and should be used with caution in clients with electrolyte abnormalities.
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Chapters:
0:00 - Introduction
0:06 - Ondansetron (Zofran) pharmacology
0:14 - Antiemetics pharmacology
0:37 - Ondansetron mechanism of action
1:05 - Ondansetron uses (Clinical indications)
1:18 - Ondansetron side effects
1:33 - Serotonin Syndrome
2:01 - Ondansetron contraindications
2:27 - Ondansetron drug interactions

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