The 2010 running was won by Canford Cliffs, with Richard Hannon the trainer this time. Hannon ended the year as Champion Trainer. Restricted to three-year-old colts, the race is a natural follow-up race for the winners of the English, Irish and French 2000 Guineas. Henrythenavigator, one of O'Brien's victorious sextet from the last decade, was the most recent horse to win both the 2000 Guineas and St James's Palace Stakes.
