An easy way to remember the causes of massive splenomegaly with mnemonics is explained in this video. Causes of massive splenomegaly include CML, CLL, hairy cell leukemia, malaria, kala azar, polycythemia vera, chronic splenic hemangiomatosis, myelofibrosis with myeloid metaplasia, sarcoidosis, Gaucher's disease, and autoimmune hemolytic anemia. The causes of massive spleen are a very high yield topic and are tested in various examinations, including USMLE, MRCP, and other PG entrance examinations.
Splenomegaly is defined as the enlargement of the spleen measured by size or weight. The spleen plays a significant role in hematopoiesis and immunosurveillance. Splenomegaly is often a sign of a serious underlying pathology, including hematological malignancies. An enlarged spleen is usually detected during a physical exam. The causes of splenic enlargement are numerous, and can be broadly divided into three categories: congestive, infiltrative, and proliferative. This video explains the reasons for the huge spleen , or massive spleen.
By definition, massive splenomegaly is present if the spleen is palpable 8 cm below the subcostal margin or if the dry weight of the spleen is more than 1000 grams.
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