Transmission: Malaria spreads through female Anopheles mosquito bites. When an infected mosquito bites a person, it injects Plasmodium sporozoites into the bloodstream.
Liver Invasion: Sporozoites travel to the liver and infect hepatocytes, multiplying rapidly without causing symptoms. This stage can last up to two weeks.
Rupture: Once matured, infected hepatocytes release merozoites into the bloodstream, initiating the symptomatic phase.
Red Blood Cell Invasion: Merozoites invade red blood cells (RBCs), where they multiply and cause RBCs to burst. This rupture releases more merozoites, leading to recurring cycles of fever and chills.
Immune Response: The body's immune system responds to infected RBCs, leading to fever and flu-like symptoms.
Sequestration: Some infected RBCs adhere to blood vessel walls, avoiding the spleen's filtration and worsening the infection.
Anemia and Complications: Repeated RBC destruction can lead to anemia and severe complications, affecting vital organs.
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