Benjamin Besse, MD, PhD, Gustave Roussy, Villejuif, France, discusses the promising results of zidesamtinib, a novel TRK-sparing ROS1 tyrosine kinase inhibitor, in patients with heavily pretreated ROS1+ non-small cell lung cancer (NSCLC). In the Phase I ARROS-1 study (NCT05118789), zidesamtinib demonstrated a favorable safety profile and encouraging efficacy in patients with advanced ROS1+ NSCLC, even in those with multiple prior therapies and resistance mutations like G2032R. Importantly, zidesamtinib showed activity in patients with brain metastases, a significant challenge in ROS1+ NSCLC. These results suggest that zidesamtinib may be a valuable treatment option for patients with this difficult-to-treat disease. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain.

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