Giant river otters and leopard do not share the environment. But let’s take instead, its heavier and more powerful cousin, the jaguars. They certainly can kill and eat giant otters, it is documented. Note that this task is much more challeging than one may think.
More often, the giant river otters can not only frustate the jaguar’s plan and also scare them off! If a bigger and stronger jaguar has difficulties with a group (they live in group, so a battle alone would not be fair), and also considering the jaguar is by far a better swimmer than a leopard, even hunting inside other, the chances for a leopard are really small.
